{"id":35581,"date":"2025-10-24T10:16:22","date_gmt":"2025-10-24T10:16:22","guid":{"rendered":"https:\/\/joomhost1.com\/leishvet\/?page_id=35581"},"modified":"2025-11-05T10:02:35","modified_gmt":"2025-11-05T10:02:35","slug":"vaccines","status":"publish","type":"page","link":"https:\/\/joomhost1.com\/leishvet\/vaccines\/","title":{"rendered":"Vaccines"},"content":{"rendered":"

[vc_row row_height_percent=”0″ back_color=”Alive-green1″ overlay_alpha=”50″ gutter_size=”3″ column_width_percent=”100″ shift_y=”0″ z_index=”0″ content_parallax=”0″ uncode_shortcode_id=”180015″ back_color_type=”uncode-palette”][vc_column column_width_percent=”100″ position_vertical=”middle” align_horizontal=”align_center” gutter_size=”3″ overlay_alpha=”50″ shift_x=”0″ shift_y=”0″ shift_y_down=”0″ z_index=”0″ medium_width=”0″ mobile_width=”0″ width=”1\/1″ uncode_shortcode_id=”122025″][vc_custom_heading auto_text=”yes” text_color=”accent” heading_semantic=”h1″ text_size=”h3″ uncode_shortcode_id=”123021″ text_color_type=”uncode-palette”]This is a custom heading element.[\/vc_custom_heading][\/vc_column][\/vc_row][vc_row][vc_column column_width_percent=”100″ gutter_size=”3″ overlay_alpha=”50″ shift_x=”0″ shift_y=”0″ shift_y_down=”0″ z_index=”0″ medium_width=”0″ mobile_width=”0″ sticky=”yes” width=”5\/12″ uncode_shortcode_id=”173105″][vc_single_image dynamic=”yes” media_width_percent=”100″ alignment=”center” advanced=”yes” media_items=”media|original,sep-one|reduced,caption” media_text=”under” media_overlay_opacity=”50″ media_h_align=”center” media_padding=”2″ media_text_reduced=”yes” uncode_shortcode_id=”366139″][\/vc_column][vc_column column_width_percent=”100″ gutter_size=”2″ overlay_alpha=”50″ shift_x=”0″ shift_y=”0″ shift_y_down=”0″ z_index=”0″ medium_width=”0″ mobile_width=”0″ width=”7\/12″ uncode_shortcode_id=”859705″][vc_column_text text_lead=”small” uncode_shortcode_id=”175176″ el_class=”text-justify”]Two vaccines which were initially commercialized are not available anymore. The first one was launched in Brazil and was based on a fucose-mannose ligand enriched with glycoprotein 63 with a saponin adjuvant and the second one, the first launched in Europe, was based on purified excreted\/secreted antigens of L. infantum<\/em> combined to a saponinlike adjuvant.<\/p>\n

The only currently available vaccine in Europe contains the active substance \u201cprotein Q\u201d, a recombinant protein containing five different antigens from L. infantum<\/em> without an additional adjuvant. First vaccination is a single injection. Booster injections are given annually.<\/p>\n

The vaccine available in Europe can only be injected to healthy seronegative dogs, 6 months of age or older, tested by a quantitative serological assay.<\/p>\n

A new DNA vaccine based on the non-replicative antibiotic resistance marker-free plasmid vector pPAL which contains an encoding gene for the L. infantum<\/em> activated protein kinase C receptor analogue (LACK) has been approved by the European Medicines Agency in 2023. This vaccine can only be administered via intranasal, to healthy dogs of 6 months of age or older.<\/p>\n

All of these vaccines do not prevent infection but do alter disease progression and the probability of progression to clinically overt disease.[\/vc_column_text][\/vc_column][\/vc_row][vc_row row_height_percent=”0″ override_padding=”yes” h_padding=”2″ top_padding=”2″ bottom_padding=”4″ back_color=”color-lxmt” overlay_alpha=”50″ gutter_size=”3″ column_width_percent=”100″ shift_y=”0″ z_index=”0″ content_parallax=”0″ uncode_shortcode_id=”155729″ back_color_type=”uncode-palette”][vc_column column_width_percent=”100″ gutter_size=”2″ overlay_alpha=”50″ shift_x=”0″ shift_y=”0″ shift_y_down=”0″ z_index=”0″ medium_width=”0″ mobile_width=”0″ width=”1\/1″ uncode_shortcode_id=”395019″][vc_custom_heading text_color=”Alive-green5″ text_size=”h5″ uncode_shortcode_id=”133878″ text_color_type=”uncode-palette”]Table 7. Current anti-Leishmania<\/em> vaccines for 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Two vaccines which were initially commercialized are not available anymore. The first one was launched ...<\/p>\n","protected":false},"author":2,"featured_media":35585,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"inline_featured_image":false,"footnotes":""},"class_list":["post-35581","page","type-page","status-publish","has-post-thumbnail","hentry","page_category-canine-factsheet"],"yoast_head":"\nVaccines - LeishVet<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/joomhost1.com\/leishvet\/vaccines\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Vaccines - LeishVet\" \/>\n<meta property=\"og:description\" content=\"Two vaccines which were initially commercialized are not available anymore. 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